WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:TGF-beta signaling pathway       ID:04350
C=84; O=10; E=1.08; R=9.27; rawP=1.33e-07; adjP=1.38e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000011465 NA DCN decorin 1634 ENSG00000011465
2  ENSG00000049323 NA LTBP1 latent transforming growth factor beta binding protein 1 4052 ENSG00000049323
3  ENSG00000143768 NA LEFTY2 left-right determination factor 2 7044 ENSG00000143768
4  ENSG00000156466 NA GDF6 growth differentiation factor 6 392255 ENSG00000156466
5  ENSG00000113296 NA THBS4 thrombospondin 4 7060 ENSG00000113296
6  ENSG00000125378 NA BMP4 bone morphogenetic protein 4 652 ENSG00000125378
7  ENSG00000105664 NA COMP cartilage oligomeric matrix protein 1311 ENSG00000105664
8  ENSG00000153162 NA BMP6 bone morphogenetic protein 6 654 ENSG00000153162
9  ENSG00000102882 NA MAPK3 mitogen-activated protein kinase 3 5595 ENSG00000102882
10  ENSG00000143869 NA GDF7 growth differentiation factor 7 151449 ENSG00000143869


Database:KEGG pathway       Name:Axon guidance       ID:04360
C=129; O=10; E=1.66; R=6.03; rawP=7.08e-06; adjP=0.0004
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000044524 NA EPHA3 EPH receptor A3 2042 ENSG00000044524
2  ENSG00000182168 NA UNC5C unc-5 homolog C (C. elegans) 8633 ENSG00000182168
3  ENSG00000010810 NA FYN FYN oncogene related to SRC, FGR, YES 2534 ENSG00000010810
4  ENSG00000148948 NA LRRC4C leucine rich repeat containing 4C 57689 ENSG00000148948
5  ENSG00000184347 NA SLIT3 slit homolog 3 (Drosophila) 6586 ENSG00000184347
6  ENSG00000106123 NA EPHB6 EPH receptor B6 2051 ENSG00000106123
7  ENSG00000145147 NA SLIT2 slit homolog 2 (Drosophila) 9353 ENSG00000145147
8  ENSG00000092421 NA SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 57556 ENSG00000092421
9  ENSG00000066248 NA NGEF neuronal guanine nucleotide exchange factor 25791 ENSG00000066248
10  ENSG00000102882 NA MAPK3 mitogen-activated protein kinase 3 5595 ENSG00000102882


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=11; E=2.57; R=4.28; rawP=6.24e-05; adjP=0.0022
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000010810 NA FYN FYN oncogene related to SRC, FGR, YES 2534 ENSG00000010810
2  ENSG00000116473 NA RAP1A RAP1A, member of RAS oncogene family 5906 ENSG00000116473
3  ENSG00000077943 NA ITGA8 integrin, alpha 8 8516 ENSG00000077943
4  ENSG00000113296 NA THBS4 thrombospondin 4 7060 ENSG00000113296
5  ENSG00000091136 NA LAMB1 laminin, beta 1 3912 ENSG00000091136
6  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
7  ENSG00000170962 NA PDGFD platelet derived growth factor D 80310 ENSG00000170962
8  ENSG00000132470 NA ITGB4 integrin, beta 4 3691 ENSG00000132470
9  ENSG00000105664 NA COMP cartilage oligomeric matrix protein 1311 ENSG00000105664
10  ENSG00000109339 NA MAPK10 mitogen-activated protein kinase 10 5602 ENSG00000109339
11  ENSG00000102882 NA MAPK3 mitogen-activated protein kinase 3 5595 ENSG00000102882


Database:KEGG pathway       Name:ECM-receptor interaction       ID:04512
C=85; O=7; E=1.09; R=6.41; rawP=0.0001; adjP=0.0026
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000132470 NA ITGB4 integrin, beta 4 3691 ENSG00000132470
2  ENSG00000188157 NA AGRN agrin 375790 ENSG00000188157
3  ENSG00000105664 NA COMP cartilage oligomeric matrix protein 1311 ENSG00000105664
4  ENSG00000077943 NA ITGA8 integrin, alpha 8 8516 ENSG00000077943
5  ENSG00000159164 NA SV2A synaptic vesicle glycoprotein 2A 9900 ENSG00000159164
6  ENSG00000113296 NA THBS4 thrombospondin 4 7060 ENSG00000113296
7  ENSG00000091136 NA LAMB1 laminin, beta 1 3912 ENSG00000091136


Database:KEGG pathway       Name:Neuroactive ligand-receptor interaction       ID:04080
C=272; O=12; E=3.49; R=3.43; rawP=0.0002; adjP=0.0035
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000170214 NA ADRA1B adrenoceptor alpha 1B 147 ENSG00000170214
2  ENSG00000164220 NA F2RL2 coagulation factor II (thrombin) receptor-like 2 2151 ENSG00000164220
3  ENSG00000161509 NA GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2905 ENSG00000161509
4  ENSG00000136928 NA GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 9568 ENSG00000136928
5  ENSG00000135914 NA HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 3357 ENSG00000135914
6  ENSG00000182771 NA GRID1 glutamate receptor, ionotropic, delta 1 2894 ENSG00000182771
7  ENSG00000171596 NA NMUR1 neuromedin U receptor 1 10316 ENSG00000171596
8  ENSG00000180772 NA AGTR2 angiotensin II receptor, type 2 186 ENSG00000180772
9  ENSG00000181104 NA F2R coagulation factor II (thrombin) receptor 2149 ENSG00000181104
10  ENSG00000116678 NA LEPR leptin receptor 3953 ENSG00000116678
11  ENSG00000147145 NA LPAR4 lysophosphatidic acid receptor 4 2846 ENSG00000147145
12  ENSG00000164128 NA NPY1R neuropeptide Y receptor Y1 4886 ENSG00000164128


Database:KEGG pathway       Name:Metabolic pathways       ID:01100
C=1130; O=30; E=14.52; R=2.07; rawP=0.0002; adjP=0.0035
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000081181 NA ARG2 arginase, type II 384 ENSG00000081181
2  ENSG00000115361 NA ACADL acyl-CoA dehydrogenase, long chain 33 ENSG00000115361
3  ENSG00000154027 NA AK5 adenylate kinase 5 26289 ENSG00000154027
4  ENSG00000187091 NA PLCD1 phospholipase C, delta 1 5333 ENSG00000187091
5  ENSG00000043514 NA TRIT1 tRNA isopentenyltransferase 1 54802 ENSG00000043514
6  ENSG00000147383 NA NSDHL NAD(P) dependent steroid dehydrogenase-like 50814 ENSG00000147383
7  ENSG00000100413 NA POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) 171568 ENSG00000100413
8  ENSG00000169359 NA SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 9197 ENSG00000169359
9  ENSG00000144278 NA GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) 114805 ENSG00000144278
10  ENSG00000182197 NA EXT1 exostosin 1 2131 ENSG00000182197
11  ENSG00000065154 NA OAT ornithine aminotransferase 4942 ENSG00000065154
12  ENSG00000166548 NA TK2 thymidine kinase 2, mitochondrial 7084 ENSG00000166548
13  ENSG00000123453 NA SARDH sarcosine dehydrogenase 1757 ENSG00000123453
14  ENSG00000197594 NA ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 5167 ENSG00000197594
15  ENSG00000244038 NA DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase 1650 ENSG00000244038
16  ENSG00000157064 NA NMNAT2 nicotinamide nucleotide adenylyltransferase 2 23057 ENSG00000157064
17  ENSG00000128918 NA ALDH1A2 aldehyde dehydrogenase 1 family, member A2 8854 ENSG00000128918
18  ENSG00000176387 NA HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 3291 ENSG00000176387
19  ENSG00000162882 NA HAAO 3-hydroxyanthranilate 3,4-dioxygenase 23498 ENSG00000162882
20  ENSG00000163655 NA GMPS guanine monphosphate synthetase 8833 ENSG00000163655
21  ENSG00000101444 NA AHCY adenosylhomocysteinase 191 ENSG00000101444
22  ENSG00000159231 NA CBR3 carbonyl reductase 3 874 ENSG00000159231
23  ENSG00000136699 NA SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 55627 ENSG00000136699
24  ENSG00000158850 NA B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 8703 ENSG00000158850
25  ENSG00000165092 NA ALDH1A1 aldehyde dehydrogenase 1 family, member A1 216 ENSG00000165092
26  ENSG00000135929 NA CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1593 ENSG00000135929
27  ENSG00000128309 NA MPST mercaptopyruvate sulfurtransferase 4357 ENSG00000128309
28  ENSG00000142920 NA ADC arginine decarboxylase 113451 ENSG00000142920
29  ENSG00000144057 NA ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 84620 ENSG00000144057
30  ENSG00000135318 NA NT5E 5'-nucleotidase, ecto (CD73) 4907 ENSG00000135318


Database:KEGG pathway       Name:mRNA surveillance pathway       ID:03015
C=83; O=6; E=1.07; R=5.63; rawP=0.0007; adjP=0.0104
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000156475 NA PPP2R2B protein phosphatase 2, regulatory subunit B, beta 5521 ENSG00000156475
2  ENSG00000125755 NA SYMPK symplekin 8189 ENSG00000125755
3  ENSG00000174740 NA PABPC5 poly(A) binding protein, cytoplasmic 5 140886 ENSG00000174740
4  ENSG00000254535 NA PABPC4L poly(A) binding protein, cytoplasmic 4-like 132430 ENSG00000254535
5  ENSG00000090621 NA PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) 8761 ENSG00000090621
6  ENSG00000205937 NA RNPS1 RNA binding protein S1, serine-rich domain 10921 ENSG00000205937


Database:KEGG pathway       Name:Hedgehog signaling pathway       ID:04340
C=56; O=5; E=0.72; R=6.95; rawP=0.0008; adjP=0.0104
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000125378 NA BMP4 bone morphogenetic protein 4 652 ENSG00000125378
2  ENSG00000074047 NA GLI2 GLI family zinc finger 2 2736 ENSG00000074047
3  ENSG00000153162 NA BMP6 bone morphogenetic protein 6 654 ENSG00000153162
4  ENSG00000111087 NA GLI1 GLI family zinc finger 1 2735 ENSG00000111087
5  ENSG00000112210 NA RAB23 RAB23, member RAS oncogene family 51715 ENSG00000112210


Database:KEGG pathway       Name:Tight junction       ID:04530
C=132; O=7; E=1.70; R=4.13; rawP=0.0016; adjP=0.0185
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000156475 NA PPP2R2B protein phosphatase 2, regulatory subunit B, beta 5521 ENSG00000156475
2  ENSG00000079819 NA EPB41L2 erythrocyte membrane protein band 4.1-like 2 2037 ENSG00000079819
3  ENSG00000060138 NA CSDA cold shock domain protein A 8531 ENSG00000060138
4  ENSG00000133026 NA MYH10 myosin, heavy chain 10, non-muscle 4628 ENSG00000133026
5  ENSG00000125755 NA SYMPK symplekin 8189 ENSG00000125755
6  ENSG00000131899 NA LLGL1 lethal giant larvae homolog 1 (Drosophila) 3996 ENSG00000131899
7  ENSG00000013297 NA CLDN11 claudin 11 5010 ENSG00000013297


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=9; E=2.74; R=3.29; rawP=0.0019; adjP=0.0198
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000148180 NA GSN gelsolin 2934 ENSG00000148180
2  ENSG00000129682 NA FGF13 fibroblast growth factor 13 2258 ENSG00000129682
3  ENSG00000077943 NA ITGA8 integrin, alpha 8 8516 ENSG00000077943
4  ENSG00000065534 NA MYLK myosin light chain kinase 4638 ENSG00000065534
5  ENSG00000170962 NA PDGFD platelet derived growth factor D 80310 ENSG00000170962
6  ENSG00000132470 NA ITGB4 integrin, beta 4 3691 ENSG00000132470
7  ENSG00000133026 NA MYH10 myosin, heavy chain 10, non-muscle 4628 ENSG00000133026
8  ENSG00000181104 NA F2R coagulation factor II (thrombin) receptor 2149 ENSG00000181104
9  ENSG00000102882 NA MAPK3 mitogen-activated protein kinase 3 5595 ENSG00000102882




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).